University of Wisconsin–Madison

Data Science to Promote Precision Medicine

The Data Science Core was established through a Data Science to Promote Precision Medicine grant funded through the Wisconsin Partnership Program (WPP). The Data Science Core provides essential data science and omics support and training for SMPH researchers, faculty, and students, empowering them with the tools to drive impactful discoveries.

Collaboration Model

The Data Science Core operates as active scientific co-investigators funded via grant percentage effort, not as an hourly IT shop or fee-for-service facility. We partner from project design through analysis to dissemination. To maximize grant competitiveness, we may be able to provide limited, exploratory pre-award prototyping to generate preliminary figures and demonstrate feasibility to reviewers.

Capabilities & Lifecycle Support

Delivering end-to-end technical, regulatory, and grant support across core areas:

  • Genomics & Bioinformatics: Standardized Nextflow pipelines (RNA-seq, variant calling) and cBioPortal data platform analyses/training.
  • Secure AI & Machine Learning: Custom ML/NLP workflows and PHI-compliant LLM access via Azure AI Foundry.
  • Computer Vision: Medical image feature extraction, segmentation, and classification.
  • Multimodal Integration: Combining EHR, molecular, and imaging data for precision medicine.
  • Lifecycle Resources: Technical grant text, IRB compliance language, data delivery navigation, and manuscript co-authoring.

How It Works

  1. Consult: We review your research goals, assess data availability, and determine project fit.
  2. Align: We co-develop the proposal concept, draft a Project Charter, and finalize grant effort.
  3. Execute: An assigned data scientist runs the targeted analysis plan and manages HPC resources.
  4. Deliver: We translate data into insights, co-author publications, and design future aims.

Principal Investigators

Jomol Mathew
Co-Principal Investigator
jomol.mathew@wisc.edu

Dustin Deming
Co-Principal Investigator ddeming@medicine.wisc.edu

Amitha Domalpally
Co-Principal Investigator domalpally@wisc.edu